Biodegradable Elastic Sponge from Nanofibrous Biphasic Calcium Phosphate Ceramic as an Advanced Material for Regenerative Medicine

Biodegradable porous calcium phosphate (CaP) ceramics are widely used as synthetic graft substitutes for bone regeneration, owing to their chemical and structural similarity associated bioactivity in terms of bone-bonding, osteoconductive, even osteoinductive properties. Nevertheless, the intrinsic brittleness poor processability CaP strongly impair clinical applicability. Herein, a biphasic (BCP) sponge is developed that consists self-supporting network seamlessly interwoven hydroxyapatite nanowires ?-tricalcium nanofibers possesses highly interconnected structure with open cell geometry ultrahigh porosity. Owing its unique properties, ceramic can be easily processed into various shapes dimensions, such cylindrical scaffolds thin, flexible membranes. Moreover, BCP introduced defect compacted or folded state from syringe and, upon wetting, expand original shape, thereby filling cavity. The nanofibrous gradually degrades vitro rapidly mineralizes when immersed simulated body fluid. it adsorbs significantly more proteins than conventional ceramic. Finally, supports attachment, proliferation, osteogenic differentiation human mesenchymal stromal cells comparable